Blood protein markers play an important role in the diagnosis of acute myocardial infarction (AMI) and acute coronary syndrome (ACS). Cardiac troponin-I (Tn-I), creatine kinase (CK-MB), and myoglobin are key members of them. CK–MB levels can be considered as an important diagnostic indicator of myocardial infarction and has been found to be more sensitive and early indicator of myocardial injury. Tn-I is more reliable than creatine kinase as a prognostic marker in people with ischemic chest pain. Myoglobin is a promising cardiac marker when other markers such as CK-MB and Tn-I as well as other indicators like clinical signs and ECG are taken into account for diagnosis/confirmation of AMI.. The Myoglobin/CK-MB/Troponin I Combo Rapid Test is a rapid chromatographic immunoassay for the qualitative detection of human Myoglobin, CK-MB and cardiac Troponin I in whole blood, serum or plasma as an aid in the diagnosis of myocardial infarction (MI).