Syphilis is a sexually transmitted infection (STI) that, when left untreated, can progress to a late stage that causes serious health problems. The infection alternates with periods of being active and inactive (latent). When the infection is active, symptoms occur. But when the infection is latent, no symptoms appear even though you still have syphilis. Syphilis is caused by a type of bacterium (Treponemapallidum) that usually enters the body through the mucous membranes. If not treated, syphilis may linger and may progress to the late stage where more serious health problems, such as blindness, heart disorders, mental disorders, nervous system problems, and even death. The serum or plasma test for TreponemaPallidum (TPHA) can be utilized as a rapid screening process for large populations of patients and highly indicated in the early diagnosis of Syphilis infection as the immune response can often precede clinical manifestations of disease. The One Step Syphilis Test is a solid phase immunochromatographic assay (Recombinant TP, 15kDa, 17kDa antigens used as captures and detectors) for the qualitative detection of antibodies of all isotypes (IgG, IgM, IgA) against Treponemapallidum (TP).